Reproductive proteins maintain species‐specific barriers to fertilization, affect the outcome of sperm competition, mediate reproductive conflicts between the sexes, and potentially contribute to the formation of new species. However, the specific proteins and molecular mechanisms that underlie these processes are understood in only a handful of cases. Advances in genomic and proteomic technologies enable the identification of large suites of reproductive proteins, making it possible to dissect reproductive phenotypes at the molecular level. We first review these technological advances and describe (...) how reproductive proteins are identified in diverse animal taxa. We then discuss the dynamic evolution of reproductive proteins and the potential selective forces that act on them. Finally, we describe molecular and genomic tools for functional analysis and detail how evolutionary data may be used to make predictions about interactions among reproductive proteins. (shrink)

The “top-down” and “bottom-up” approaches have been thought to exhaust the possibilities for doing cognitive neuroscience. We argue that neither approach is likely to succeed in providing a theory that enables us to understand how cognition is achieved in biological creatures like ourselves. We consider a promising third way of doing cognitive neuroscience, what might be called the “neural dynamic systems” approach, that construes cognitive neuroscience as an autonomous explanatory endeavor, aiming to characterize in its own terms the states and (...) processes responsible for brain-based cognition. We sketch the basic motivation for the approach, describe a particular version of the approach, so-called ‘Dynamic Causal Modeling’ (DCM), and consider a concrete example of DCM. This third way, we argue, has the potential to avoid the problems that afflict the other two approaches. (shrink)

Despite acknowledgment that performance failure among new salespeople is a prevalent issue for organizations, researchers do not fully understand the consequences of repetitive periods of failure on new salespeople’s unethical selling behaviors. Further, little is known about how a sales force’s reward structure and managerial attempts to intervene following failure affect new salespeople’s behavior. Combining an experiment with longitudinal growth models, we show that repetitive periods of failure increase unethical behaviors, and interventions intended to remind the salesperson to behave in (...) the customer’s best interests attenuate this effect under a non-contingent reward structure. However, counter to managerial assumptions, under a contingent reward structure these customer-oriented interventions actually backfire by amplifying the original relationship between repetitive failure and unethical behaviors. The results have potentially important managerial implications for those who manage new salespeople learning how to sell or during other failure-prone periods. (shrink)

The biblical healings by Jesus and the primitive Church, the liturgical development of the Roman Rite of Exorcism, and the current practice of exorcists reflect a relationship between exorcism and the medical healing arts. Since mutuality characterizes all healer–sufferer interactions, informed consent is a central concept in physician–patient and exorcist–energumen relationships. Informed consent requires adequate information, decision-maker competence, and freedom from coercion. The determination of freedom from coercion is a particular challenge in exorcism, and guidelines for its assess­ment are discussed. (...) While proxy decision making in medical care is generally driven by concerns over competence, foreseeable periods of demonic coercion will necessitate establishing proxies in exorcism. This places a moral duty on the exorcist to establish a substitute decision maker even in cases where the energumen would be considered competent. Discussion of this need through the process of informed consent builds the trust necessary for mutual decision making. (shrink)

In the light of contemporary allelopathic research, the intuitively based statements of the early botanists stand up surprisingly well. The walnut tree is now understood to affect the growth of neighboring plants via juglone leached from the leaves, roots, and fruits.118 The replant or soil sickness problem of peach orchards has been related to the toxigenic breakdown of amygdalin, a constituent of peach roots.119 The declining yield of many crop species grown under continuous monoculture has been linked to the accumulation (...) of allelopathic substances in the soil, especially through the mediation of microorganisms.120 Numerous plants cited by de Candolle as being injurious, such as Erigeron,121 thistle (Cirsium),122 flax (Linum),123 and various crucifers (such as Brassica nigra),124 have been found to posses marked allelopathic activity. Over fifty years before the discovery of rhizobia, de Candolle considered the excretory material of legumes to be beneficial to cereals.125Modern reviews of allelopathy commonly credit de Candolle with an insight that was not equaled by the technology of his era.126 In fairness to his detractors, his toxin theory of plant interactions was largely the by-product of an outdated and misconstrued notion of plant nutrition. His critics and most earlier botanists had similarly erred in seeking a single factor responsible for plant growth, much as had the alchemists sought the legendary philosopher's stone. Taking all this into account and considering the forceful personality of Liebig, one can readily appreciate how, 130 years ago, Liebig's theories preempted and stifled those of de Candolle.Today, with modern techniques of plant physiology and soil biochemistry, allelopathy has been shown to be a real but subtle factor in the dynamics of natural and agricultural plant communities. It is unfortunate that the single-mindedness characteristic of previous centuries still persists. The dichotomy between allelopathy and competition is exacerbated by the inherited bias toward the nutritional model of plant interaction fostered by Liebig, and is accentuated in the fact that in modern nutritional studies it is still basically unnecessary to consider plant-plant chemical interactions and their concomitant effects, whereas in allelopathic investigations the converse is regarded as axiomatic.In summary, de Candolle should not be seen as “a prophet crying in the wilderness,” as Fisher would have it.127 The bases of de Candolle's concept of allelopathy were the dubious experiments of Macaire and his own obsolete theory of plant nutrition. Despite this, modern experimental work indicates that allelopathy is important in many plant interactions. De Candolle seems to have been right, at least in part—but for the wrong reasons. (shrink)

Primordial emotions are the subjective element of the instincts which are the genetically programmed behaviour patterns which contrive homeostasis. They include thirst, hunger for air, hunger for food, pain and hunger for specific minerals etc.There are two constituents of a primordial emotion—the specific sensation which when severe may be imperious, and the compelling intention for gratification by a consummatory act. They may dominate the stream of consciousness, and can have plenipotentiary power over behaviour.It is hypothesized that early in animal evolution (...) complex reflex mechanisms in the basal brain subserving homeostatic responses, in concert with elements of the reticular activating system subserving arousal, melded functionally with regions embodied in the progressive rostral development of the telencephalon. This included the emergent limbic and paralimbic areas, and the insula. This phylogenetically ancient organization subserved the origin of consciousness as the primordial emotion, which signalled that the organisms existence was immediately threatened. Neuroimaging confirms major activations in regions of the basal brain during primordial emotions in humans. The behaviour of decorticate humans and animals is discussed in relation to the possible existence of primitive awareness.Neuroimaging of the primordial emotions reveals that rapid gratification of intention by a consummatory act such as ingestion causes precipitate decline of both the initiating sensation and the intention. There is contemporaneous rapid disappearance of particular regions of brain activation which suggests they may be part of the jointly sufficient and severally necessary activations and deactivations which correlate with consciousness [Crick, F. & Koch, C. . A framework for consciousness. NatureNeuroscience,6, 119–126]. (shrink)

Chloride channels are probably found in every cell, from bacteria to mammals. Their physiological tasks range from cell volume regulation to stabilization of the membrane potential, signal transduction, transepithelial transport and acidification of intracellular organelles. These different functions require the presence of many distinct chloride channels, which are differentially expressed and regulated by various stimuli. These include various intracellular messengers (like calcium and cyclic AMP), pH, extracellular ligands and transmembrane voltage. Three major structural classes of chloride channels are known to (...) date, but there may be others not yet identified. After an overview of the general functions of chloride channels, this review will focus on these cloned chloride channels: the CLC chloride channel family, which includes voltage‐gated chloride channels, and the cystic fibrosis transmembrane regulator (CFTR), which performs other functions in addition to being a chloride channel. Finally, a short section deals with GABA and glycine receptors. Diseases resulting from chloride channel defects will be specially emphasized, together with the somewhat limited information about how these proteins work at the molecular level. (shrink)

Pharmacological cognitive enhancements nontherapeutically improve cognitive functioning, though recent critics have challenged their use by claiming that cognitive success, aided by the use of cognitive enhancement, is less valuable than otherwise. We criticize two recent responses to this objection, due to Carter and Pritchard and Wang, and propose a different response on behalf of proponents of cognitive enhancement that is shown to be more promising.

Presents a plethora of approaches to developing human potential in areas not conventionally addressed. Organized in two parts, this international collection of essays provides viable educational alternatives to those currently holding sway in an era of high-stakes accountability.

James questions the validity of the very tentative statement made in the final sentence of our paper. Our claim concerned the proportion of twins in Britain in the 1990s that might have arisen through subfertility treatment and was linked to the suggestion that the natural twinning rate might still be in decline. If this were true, we, like James, would regard that prospect with concern.

Kieran Egan; Development in Education, Journal of Philosophy of Education, Volume 18, Issue 2, 30 May 2006, Pages 187–193, https://doi.org/10.1111/j.1467-9752.1.

In his presidential address on “Symbols, Signs, and Signals,” given before the Association for Symbolic Logic, December 28, 1938, Professor C. J. Ducasse made and important distinction between what he there called the indicative and the quiddative symbol. He remarked in passing that he thought it possible to show that: 1) “The same entity may function both as indicative and as quiddative symbol: or one part of a complex symbol may be quiddative and another indicative”; and 2) “the difference between (...) the two roles is irreducible: the indicative is not a species of the quiddative nor vice versa.” An indicative symbol is defined as “one of which the distinctive property is to orient our attention to some place in an order system …”; and a quiddative symbol as “one of which the distinctive property is to make us conceive a certain kind of thing—a certain ‘what'—no matter where in any order system it may or may not be existing.”. (shrink)

The new edition of Chariton's novel Chaireas and Callirhoe by Mr. Warren E. Blake has a twofold merit: it is founded on a new and accurate collation of the only extant manuscript, a Florentinus, and it gives a full collection of the conjectures in and since the editio princeps by D'Orville . The new text has already provoked some suggestions by Prof. H. J. Rose in C.Q. xxxiii, 1939, 30, but I should like to propose alterations in some more passages.

Glückwunsch, von W. Jaeger.--Grenzsituationen der Gegenwart, von A. Wenzl.--Theologische Ontologie, von G. Jacoby.--Wissenschaft, Philosophie, Weltanschauung. von J. Barion.--Theorie und Ideologie in der Politik, von Cabralde Moncada.--Nikolai Berdjajew im bolschewistischen Russland, von F. Stepun.--Spinoza-Sokrates-Christus, der Menschensohn und die Philosophen, von H. Schuster.--Wertung und Wirksamkeit der Frau in der christlichen Kirche, von F. Heiler.--Ein neues Dogma? Von O. Schroeder.--Anbrosius von Mailand und sein Verhältnis zum Judentum, von W. Wilbrand.--Das Bild Luthers bei Johannes Hessen, von P. Althaus.--Zur Mystik Augustins, von W. falkenhahn.-Johannes Hessen (...) und Rudolf Ottos "Religlöser Menschheitsbund," von C. Barth.--Eine Antithese zum Jahre 1933, Johannes Hessens prophetische Mahnworte, von T. Pöhler.--Der Lehrer, von H. Höttges. (shrink)